English
聯系我們
網站地圖
郵箱
舊版回顧



肝臟中發現新型“肥胖因子”

文章來源:科技日報 楊雪 劉志偉   發布時間:2019-05-10  【字號:     】  

  近日,武漢大學生命科學學院宋保亮教授團隊發現,肝臟分泌的GPNMB蛋白,是一個新的“肥胖因子”,它通過上調脂肪組織的脂質合成基因、抑制機體產熱,最終引起肥胖及胰島素抵抗,而利用抗體中和血液GPNMB對肥胖和糖尿病有良好治療效果。

  近日,《自然》子刊《自然·代謝》在線發表了這項研究成果。同期雜志也發表預告對此進行了專題報道。論文題為《肝臟分泌的GPNMB蛋白促進白色脂肪組織脂質合成、加劇肥胖和胰島素抵抗》。

  根據世界衛生組織統計,2016年,18歲及以上的成年人中逾19億人超重,其中超過6.5億人肥胖。肥胖可受遺傳和環境等多因素影響,它不光影響體型,還是糖尿病、脂肪肝和心腦血管等疾病的重要危險因素。生命體作為一個有機整體,其脂質代謝過程除了在細胞內受到嚴格的調控之外,各個組織器官之間也存在多種形式的相互作用。

  宋保亮前期研究發現,在肝臟中特異敲除泛素連接酶gp78(L-gp78-/-)可導致SREBP通路抑制。有趣的是,研究人員發現在肝臟合成脂質能力下降的同時,脂肪組織脂質合成能力會代償性上調,這表明肝臟分泌某種“肥胖因子”,促進脂肪組織脂質合成。

  從這個現象出發,研究人員發現了肝臟分泌的GPNMB蛋白能顯著加重肥胖程度,增加脂肪組織脂質合成能力,抑制機體產熱,降低能量消耗,加重胰島素抵抗。而GPNMB中和抗體能有效逆轉肥胖小鼠的表型,減少脂肪組織重量,降低脂肪組織脂質合成基因的表達,促進脂肪組織產熱,并減輕胰島素抵抗。該研究成果表明,GPNMB就是一個新型“肥胖因子”,并證明靶向GPNMB可有效治療肥胖和糖尿病。




(責任編輯:侯茜)

附件:

專題推薦

相關新聞


© 1996 - 中國科學院 版權所有 京ICP備05002857號  京公網安備110402500047號  聯系我們

地址:北京市三里河路52號 郵編:100864

天地彩www.3tdc.com www.627300.com | 984694.com | 872630.com | www.uo78.com | www.83gn.com | www.7393.win | www.926885.com | 760369.com | 562021.com | www.cp2100.com | www.87ss.com | www.9119.bid | www.026097.com | www.222456.com | www.497313.com | www.949913.com | 274573.com | 盛大彩票www.ct8822.com | www.rp23.com | www.9xr.com | www.7408.pw | www.67299.com | www.309891.com | www.791264.com | www.fz3.cc | www.54mh.com | www.6520.biz | www.91332.com | www.167779.com | www.635660.com | 503601.com | 423333.com | www.dj74.cc | www.153678.com | www.563648.com | www.692176.com | 178195.com | 818合彩www.www.9889hc.com | www.tp88.cc | www.6641.xyz | www.69638.cc | www.121422.com | www.338261.com | www.597316.com | www.766929.com | www.82896.cc | www.152287.com | www.503111.cc | www.748786.com | www.863745.com | 979528.com | 彩票大家乐www.21202v.com | www.03615.com | www.233979.com | www.449432.com | www.713793.com | 026407.com | 254379.com | 36621.com | www.uv62.com | www.132109.com | www.355872.com | www.542363.com | www.772858.com | 320359.com | www.35qr.com | www.8877.pro | www.123433.com | www.286959.com | www.696699.com | www.872184.com | 996008.com | 彩票5www.534658.com | www.i56.cc | www.1409.xyz | www.53358.com | www.278919.com | www.434300.cc | www.712448.com | www.832101.com | 天际彩票www.tj92.com | www.a82.org | www.92224.com | www.119800.com | www.594352.com | www.713466.com | www.885181.com | 215200.cc | www.566775.com | www.770172.com | www.907178.com | www.995587.com | 16uo.com | 吉利彩票www.80065f.com | www.19lj.com | www.992.cc | www.154454.com | www.382995.com | www.791070.com | www.820638.com | www.as65.com | www.09jg.com | www.93851.cc | www.074546.com | www.305484.com | www.450017.com | www.793150.com | www.917979.com | 036962.com | 金冠彩票www.49956o.com | www.ye85.com | www.88425.cc | www.186767.com | www.456286.com | www.603591.com | www.931502.com | www.1566.cc | www.183725.com | www.566158.com | www.650120.com | www.906752.com | www.991965.com | 982459.com | www.pe11.com | www.2179.win | www.16216.cc | www.48708.com | www.130701.com | www.306887.com | www.479365.com | www.824699.com | www.914938.com | www.955499.com | 976570.com | 140306.com | www.kj82.cc | www.al97.com | www.217.red | www.195770.com | www.332706.com | www.937888.cc | 01313.com | 3522.com | 449755.com | 六福彩票www.66ffu.com | www.73566.cc | www.160130.com | www.388761.com | www.622056.com | www.992822.com | 964207.com | 625795.com | 彩票5www.550249.com | www.xr98.com | www.97id.cc | www.68481.com | www.260026.com | www.420930.com | www.507908.com | www.609711.com | www.887518.com | 560090.com | 561709.com | www.ca4.cc | www.yp93.com | www.52wg.com | www.10751.com | www.970892.com | www.992433.com | cp414.com | 102723.com | www.65om.com | www.3990.biz | www.27695.cc | www.020642.com | www.211860.com | www.656757.com | www.88719.com | www.0044.tv | www.1gz.com | 771796.com | www8867.con | www.851292.com | www.801335.com | www.619107.com | www.015228.com | www.4737.com | 569580.com | www.268120.com | www.cp6632.com | www.808080.com | www.898161.com | www.673962.com | www.172316.com | www.1280.com | www.ca06.com | www.739674.com | www.26844.com | 137042.com | 百姓彩票www.bxcp3.com | www.pk9.com | www.21ou.com | www.69kq.com | www.0632.win | www.23392.com | www.005489.com | www.071200.com | www.085223.com | www.119324.com | www.125860.com | www.314001.com | www.332841.com | www.345184.com | www.380780.com | www.598362.com | www.97917.com | 554286.com | www.399757.com | www.93609.com | 749779.com | www.500066.com | www.95yi.com | www.948146.com | www.083669.com | www.zq91.cc | www.876559.com | www.109528.com | 181879.com | www.511234.com | 44416.com | 143526.com | 272299.com | 629820.com | www.254165.com | www.43bi.com | www.948549.com | www.126647.com | www.405866.com | www.023861.com | 30js.com | www.331476.com | www.11sq.com | 180118.com | www.318242.com | www.s63.net | 500彩票www.50054k.com | 954564.com | www.734178.com | www.009193.com | www.311392.com | www.mk49.com | www.982879.com | www.751146.com | www.203222.com | www.60915.com | www.6529.cc | 974587.com | 897613.com | www.694446.com | www.108759.com | www.032792.com | 大赢家彩票www.399046.com | www.948573.com | www.735707.com | www.519207.com | www.5670.in | 天天赢彩票www.73736b.com | www.868818.com | www.450165.com | www.0701.me | www.qp35.com | www.106035.com | www.48610.com | www.1927.wang | 085432.com | www.866993.com | www.218059.com | www.144136.com | www.075535.com | www.yb13.com | 263930.com | 179054.com | www.507835.com | www.088014.com | www.09135.com | 137602.com | www.337396.com | www.057207.com | www.543255.com | www.362574.com | www.483910.com | www.487522.com | www.824799.com | 505066.com | sg00.com | 496208.com | 幸运彩票www.73166l.com | www.748208.com | www.04148.cc | www.004109.com | www.037005.com | www.045287.com | www.367999.com | www.892142.com | www.912058.com | www.948409.com | www.930401.com | 894821.com | 853649.com | www.jg87.com | www.35hf.com | www.6817.org | www.8019.loan | www.38668.com | www.256963.com | www.637207.com | www.739229.com | www.702505.com | www.639786.com | 54zf.com | www.2373.cm | www.122306.com | www.183579.com | www.469426.com | www.511490.com | www.525217.com | www.739133.com | www.gs07.com | www.40wy.com | www.54dq.com | www.44kl.com | www.47ht.com | www.975.cm | www.5678.cm | www.34308.cc | www.103434.com | www.152580.com | www.472225.com | www.455713.com | www.484389.com | www.713566.com | www.792906.com | www.828944.com | www.839412.com | 9712.biz | 963248.com | 748128.com | www.77by.com | www.66309.com | www.145858.com | www.456141.com | 248561.com | 500彩票www.66653j.com | www.b37.org | www.35ey.com | www.r70.top | www.73hu.com | www.63rv.com | www.58hu.com | www.21114.com | www.055046.cc | www.120163.com | www.150476.com | www.232350.com | www.285766.cc | www.534420.com | www.626920.com | www.803343.com | www.873720.com | 同乐彩票www.tlcp7.com | www.09up.com | www.51568.com | www.818615.com | 044786.com | hx70.cc | 大赢家彩票网www.178329.com | 中彩网www.2408b.cc | www.cp7891.com | www.7865.cn | www.71347.com | www.247636.com | www.567148.com | 912816.com | 723940.com | 388252.com | 福利彩票www.99677b.com | www.qh41.com | www.14oe.com | www.25ou.com | www.245975.com | www.231377.com | www.206333.com | www.415530.com | www.452132.com | www.555278.com | www.558794.com | www.970196.com | 217669.com | cai2255.com | www.33047.com | www.73875.com | www.239816.com | www.237337.com | www.405831.com | www.502799.com | www.523913.com | 669547.com | lqcp.com | 841991.com | 142409.com | 095120.com | 964227.com | 973841.com | 973340.com | 彩之家www.55czj.com | 085028.com | 338429.com | 大赢家彩票网www.54400w.com | www.0968.cm | www.90827.com | www.61103.com | www.058910.com | www.93006.cc | www.69jb.com | www.10373.com | www.48073.com | www.083132.com | www.198313.com | www.530829.com | www.590662.com | www.569510.com | www.798825.com | www.840834.com | www.111271.com | 721348.com | www.451268.com | www.58em.com | 947249.com | www.765411.com | www.25976.cc | 111708.com | www.365469.cc | www.58my.com | www.760531.com | www.09766.com | www.983908.com | www.065186.com | cp0777.com | www.688220.com | www.767120.com | www.779130.com | www.680385.com | www.641658.com | www.224600.com | www.hh64.com | www.699400.com | www.275594.com | www.uc2.com | www.589708.com | www.763529.com | www.774198.com | www.817002.com | www.894808.com | www.851153.com | www.726543.com | www.648851.com | www.951094.com | www.956087.com | www.871833.com | www.929024.com | www.915408.com | 82899.com | www.3642.com | www.499.live | www.99411.cc | 153350.com | www.556068.com | www.103072.com | 357685.com | www.316022.com | www.tq0.com | www.67vf.com | www.4295.vip | 504307.com | www.249941.com | www.5470.xyz | www.63073.com | www.195648.com | www.914868.com | www.879080.com | 029836.com | 500彩票网www.876433.com | 5816.me | ve69.com | 386290.com | 786005.com | 976814.com | www.um30.com | www.yo60.com | www.40lj.com | www.6ag.cc | www.50ri.com | www.34sv.com | www.07pk.com | www.5780.cm | www.9863.in | www.669872.com | www.962677.com | www.866741.com | 932851.com | www.bj64.com | www.ur48.com | www.8lk.com | www.a10.top | www.034778.com | www.024817.cc | www.030045.com | www.038039.com | www.119785.com | www.119558.com | www.071778.com | www.81600.com | www.383330.com | www.17807.com | www.48035.com | www.059097.com | www.019130.com | www.022222.com | www.080811.com | www.344737.com | www.202018.com | www.263716.com | www.548236.com | www.506704.com | www.390314.com | www.504766.com | www.774054.com | www.936208.com | www.849499.com | 0838.date | www.970018.com | 627580.com | 5288.com | 278076.com | www.960542.com | www.796816.com | 397320.com | 36789.com | 155009.com | 485169.com | www.517690.com | www.428509.com | www.308006.com | www.244768.com | www.247900.com | www.232470.com | www.305075.com | www.246843.com | www.236657.com | www.162260.com | www.293625.com | www.286877.com | www.233647.com | www.123011.cc | www.108493.com | www.060881.com | www.63100.com | www.fw53.com | www.572002.com | www.362.me | 209091.com | www.172253.com | 500彩票网www.65707e.com | www.550768.com | www.320.site | www.966854.com | www.001521.com | 930253.com | www.358049.com | www.39bh.com | www.690761.com | www.129694.com | www.pf2.cc | www.587548.com | www.7565.cc | 756160.com | www.220383.com | 幸运彩票www.550116.com | 791607.com | www.390652.com | www.927505.com | www.846517.com | www.318419.com | www.507080.com | www.661665.com | www.31799.cc | www.956071.com | www.979650.com | www.2581.vip | www.701.biz | www.90sl.com | www.00ic.com | www.um9.com | 47316.cc | www.072.biz | www.11js.cc | www.kf17.com | www.zv37.com | 090768.com | www.303319.com | www.uj66.com | www.682196.com | www.958329.com | www.790169.com | www.908224.com | www.777681.com | www.844807.com | www.007744.com | www.876888.cc | www.931558.com | www.780700.com | www.882582.com | www.683748.com | www.538436.com | www.443110.com | www.183510.com | www.086490.com | www.78225.com | www.60339.com | www.61193.cc | www.c51.club | www.737656.com | www.095135.com | 600彩票www.336766.com | www.w36.com | 229306.com | www.715588.com | www.898278.com | www.825566.com | www.629035.com | www.774782.com | www.681272.com | www.456909.com | www.369936.com | www.491988.com | www.317345.com | www.200605.com | www.028812.com | www.54711.com | www.84375.com | www.786112.com | www.669301.com | www.500366.cc | www.509610.com | 134138.cc | 37711.com | 61238.cc | 081803.com | 025720.com | www.980570.com | www.933632.com | www.805712.com | www.872003.com | www.915796.com | www.801233.com | www.669191.com | www.562709.com | www.365226.com | www.453046.com | www.342522.com | www.596362.com | www.677148.com | www.788685.com | 082612.com | www.333454.com | 200600.com | 739502.com | 爱购彩票www.3552o.com | www.bq88.com | 吉利彩票www.80065x.com | 724015.com | 406988.com | www.923881.com | www.798258.com | www.711739.com | www.565854.com | www.286715.com | www.347911.com | www.133900.com | www.280698.com | www.1134